Quinones as an Efficient Molecular Scaffold in the Antibacterial/Antifungal or Antitumoral Arsenal

Int J Mol Sci. 2022 Nov 15;23(22):14108. doi: 10.3390/ijms232214108.

Abstract

Quinone-based compounds constitute several general classes of antibiotics that have long shown unwavering efficiency against both Gram-positive and Gram-negative microbial infections. These quinone-based antibiotics are increasingly popular due to their natural origins and are used in natural beverages from herbs or plants in African, Chinese and Indian traditional medicines to treat and prevent various diseases. Quinone-based antibiotics display different bioactive profiles depending on their structures and exert specific biocidal and anti-biofilm properties, and based on recent literature, will be discussed herein.

Keywords: antibiofilm; antifungal; biocidal properties; quinones.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Antifungal Agents*
  • Biofilms
  • Quinones* / pharmacology

Substances

  • Antifungal Agents
  • Quinones
  • Anti-Bacterial Agents

Grants and funding

This work was supported by the Centre National de la Recherche Scientifique (CNRS), the ministère de l’Enseignement Supérieur et de la Recherche (MESR) and the “National Council for Scientific and Technological Development—CNPq for the PhD fellowship “n°202125/2020-3” of M.A.D.J.