Controlling the crowd with a WNK

Liam Joseph Holt; Lance T Denes

doi:10.1016/j.cell.2022.10.027

Controlling the crowd with a WNK

Cell. 2022 Nov 23;185(24):4465-4467. doi: 10.1016/j.cell.2022.10.027.

Authors

Liam Joseph Holt¹, Lance T Denes²

Affiliations

¹ Institute for Systems Genetics, Tisch Hospital, 435 East 30th Street, New York, NY 10016, USA; Department of Biochemistry and Molecular Pharmacology at NYU Grossman School of Medicine, 435 East 30th Street, 9th Floor, Room 906, New York, NY 10016, USA. Electronic address: liam.holt@nyulangone.org.
² Institute for Systems Genetics, Tisch Hospital, 435 East 30th Street, New York, NY 10016, USA; Department of Biochemistry and Molecular Pharmacology at NYU Grossman School of Medicine, 435 East 30th Street, 9th Floor, Room 906, New York, NY 10016, USA. Electronic address: lance.denes@nyulangone.org.

Abstract

Volume control is a fundamental challenge for all cells, the mechanisms of which have been long debated. In this issue of Cell, Boyd-Shiwarski et al. find that increased molecular crowding drives condensation of WNK kinase, allowing cells to sense and respond to cell volume loss.

Controlling the crowd with a WNK

Authors

Affiliations

Abstract

Publication types

MeSH terms

Grants and funding