Case report: Surgical resection of a retro-hepatic leiomyosarcoma involving atrial reconstruction, cardiopulmonary bypass, ex vivo tumor resection, and liver re-implantation

Neel K Sharma; Uchenna Okakpu; Jeevan Murthy; Lawrence M Wei; Roberto Lopez-Solis; Carl Schmidt; Vinay Badhwar; J Wallis Marsh

doi:10.3389/fsurg.2022.1037312

Case report: Surgical resection of a retro-hepatic leiomyosarcoma involving atrial reconstruction, cardiopulmonary bypass, ex vivo tumor resection, and liver re-implantation

Front Surg. 2022 Nov 7:9:1037312. doi: 10.3389/fsurg.2022.1037312. eCollection 2022.

Authors

Neel K Sharma¹, Uchenna Okakpu², Jeevan Murthy², Lawrence M Wei³, Roberto Lopez-Solis¹, Carl Schmidt¹, Vinay Badhwar³, J Wallis Marsh¹

Affiliations

¹ Department of Surgery, West Virginia University, Morgantown, WV, United States.
² School of Medicine, West Virginia University, Morgantown, WV, United States.
³ Cardiovascular and Thoracic Surgery, West Virginia University, Morgantown, WV, United States.

Abstract

Introduction: Leiomyosarcomas (LMS) involving the inferior vena cava (IVC) is a clinically rare entity, accounting for approximately 0.5% of all adult sarcomas.

Case presentation: A 67-year-old male presented to the emergency department with mild back and lower abdominal pain. During the workup, a computed tomography scan without contrast showed an area of decreased attenuation within the liver adjacent to the intrahepatic IVC. Magnetic resonance imaging confirmed the involvement of the retro-hepatic IVC; biopsy confirmed the diagnosis of LMS. Given the location of the involvement of the retro-hepatic IVC, liver explantation was deemed necessary for adequate tumor resection. The superior extension of the tumor toward the heart necessitated Cardio-Pulmonary (CPB). The patient successfully underwent a complex surgical procedure involving liver explantation with ex vivo back-table resection of the retro-hepatic LMS, replacement of the retro-hepatic vena cava with a ringed Gore-Tex graft, liver re-implantation, and hepatic vein-atrial reconstruction under cardiopulmonary bypass. There were no intraoperative or post-op complications.

Discussion: The role of vascular reconstruction of the IVC varies depending on the level and extent of the tumor, with options ranging from primary repair, ligation, or reconstruction dictated. Surgical resection with negative margins remains the treatment of choice due to the lack of efficacy of adjuvant therapies. Importantly, liver explantation offers a chance for complete surgical resection and reconstruction. Similarly, the complex nature of the tumor necessitated a pioneering approach involving direct hepato-atrial venous anastomosis.

Conclusion: To the best of our knowledge, this is the first reported case in which the hepatic veins were anastomosed directly to the right atrium while also replacing the native vena cava with a separate graft.

Keywords: en-bloc resection; ex vivo repair; hepatic vein anastomosis; inferior vena cava; leiomyosarcoma; retroperitoneum; right atrial anastomosis.

Publication types

Case Reports