In August 2021, we detected highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b viruses in poultry in southern Benin. The isolates were genetically similar to H5N1 viruses of clade 2.3.4.4b isolated during the same period in Africa and Europe. We also found evidence for 2 separate introductions of these viruses into Benin.
Keywords: Benin; H5N1 subtype; One Health; antigenic cartography; genetic characterization; highly pathogenic avian influenza; influenza; phylogenetic analysis; poultry; respiratory infections; viruses; zoonoses.