The doubling effect of COVID-19 cases on key health indicators

PLoS One. 2022 Nov 23;17(11):e0275523. doi: 10.1371/journal.pone.0275523. eCollection 2022.

Abstract

From the beginning of the COVID-19 pandemic, researchers advised policy makers to make informed decisions towards the adoption of mitigating interventions. Key easy-to-interpret metrics applied over time can measure the public health impact of epidemic outbreaks. We propose a novel method which quantifies the effect of hospitalizations or mortality when the number of COVID-19 cases doubles. Two analyses are used, a country-by-country analysis and a multi-country approach which considers all countries simultaneously. The new measure is applied to several European countries, where the presence of different variants, vaccination rates and intervention measures taken over time leads to a different risk. Based on our results, the vaccination campaign has a clear effect for all countries analyzed, reducing the risk over time. However, the constant emergence of new variants combined with distinct intervention measures impacts differently the risk per country.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administrative Personnel
  • COVID-19* / epidemiology
  • COVID-19* / prevention & control
  • Europe / epidemiology
  • Humans
  • Pandemics / prevention & control
  • Public Health

Grants and funding

Maxime Fajgenblat acknowledges an FWO PhD FR fellowship (grant number 11E3222N). Thomas Neyens gratefully acknowledges funding by the Internal Funds KU Leuven (project number 3M190682). Christel Faes also acknowledges support from the European Union Horizon 2020 research and innovation programme - project EpiPose (grant number 101003688). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.