Approaches for the Identification of Intrinsically Disordered Protein Domains

Huqiang Wang; Zhixiang Yang; Dong Yang

doi:10.1007/978-1-0716-2784-6_28

Approaches for the Identification of Intrinsically Disordered Protein Domains

Methods Mol Biol. 2023:2581:403-412. doi: 10.1007/978-1-0716-2784-6_28.

Authors

Huqiang Wang¹, Zhixiang Yang¹, Dong Yang²

Affiliations

¹ State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China.
² State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China. yangdong@ncpsb.org.cn.

PMID: 36413333
DOI: 10.1007/978-1-0716-2784-6_28

Abstract

Intrinsically disordered protein domains are those with high disorder proportion or a consecutive disordered region. They have no stable spatial structure but play an important role in the regulation of complex cellular functions and contribute to the increasing organism complexity during evolution. Here, we describe the approaches to predict intrinsic disorder values of residues in proteins and methods to identify the intrinsically disordered domains.

Keywords: Disorder prediction; Intrinsically disordered domain; Protein domain identification.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Intrinsically Disordered Proteins*
Protein Conformation

Substances

Intrinsically Disordered Proteins