A Practical Review of the Presentation, Diagnosis, and Management of Cutaneous B-Cell Lymphomas

Nikhil Goyal; Daniel O'Leary; Joi B Carter; Nneka Comfere; Olayemi Sokumbi; Amrita Goyal

doi:10.1016/j.det.2022.07.014

A Practical Review of the Presentation, Diagnosis, and Management of Cutaneous B-Cell Lymphomas

Dermatol Clin. 2023 Jan;41(1):187-208. doi: 10.1016/j.det.2022.07.014. Epub 2022 Oct 28.

Authors

Nikhil Goyal¹, Daniel O'Leary², Joi B Carter³, Nneka Comfere⁴, Olayemi Sokumbi⁵, Amrita Goyal⁶

Affiliations

¹ Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
² Division of Hematology, Oncology, and Transplantation, University of Minnesota, 420 Delaware Street SE, MMC480, Minneapolis, MN 55455, USA.
³ Department of Dermatology, Dartmouth Geisel School of Medicine, Hanover, NH, USA.
⁴ Department of Dermatology, Mayo Clinic, 18 Old Etna Rd, Lebanon, NH 03766, USA; Department of Laboratory Medicine & Pathology, Mayo Clinic, Rochester, MN, USA.
⁵ Department of Dermatology, Mayo Clinic, Jacksonville, FL, USA; Departmen of Laboratory Medicine & Pathology, Mayo Clinic, Jacksonville, FL, USA.
⁶ Department of Dermatology, University of Minnesota, 6545 France Avenue, Ste 564, Edina, MN 55435, USA. Electronic address: goyal046@umn.edu.

PMID: 36410978
DOI: 10.1016/j.det.2022.07.014

Abstract

This review of cutaneous B-cell lymphoma (CBCL) is focused on the clinical presentation, treatment, and workup of each type of lymphoma. Part 1 is an overview of each of the CBCLs, including clinical presentation, recent advances in the pathobiology, and evidence regarding treatment strategies. Part 2 is a detailed guide to the steps in diagnosis and workup of a newly diagnosed CBCL according to the International Society for Cutaneous Lymphoma/European Organization for Research and Treatment of Cancer and NCCN guidelines.

Keywords: Cutaneous B-cell lymphoma; Cutaneous lymphoma; EBV+ mucocutaneous ulcer; Intravascular large B-cell lymphoma; Primary cutaneous B-cell lymphoma; Primary cutaneous diffuse large B-cell lymphoma; Primary cutaneous follicle center lymphoma; Primary cutaneous marginal zone lymphoma.

Publication types

Review

MeSH terms

Breast Neoplasms*
Female
Humans
Lymphoma, B-Cell* / diagnosis
Lymphoma, B-Cell* / therapy
Skin Neoplasms* / diagnosis
Skin Neoplasms* / therapy