Clinical Trials That Have Informed the Modern Management of Breast Cancer

Laura K Krecko; Meeghan A Lautner; Lee G Wilke

doi:10.1016/j.soc.2022.07.004

Clinical Trials That Have Informed the Modern Management of Breast Cancer

Surg Oncol Clin N Am. 2023 Jan;32(1):27-46. doi: 10.1016/j.soc.2022.07.004. Epub 2022 Nov 3.

Authors

Laura K Krecko¹, Meeghan A Lautner², Lee G Wilke³

Affiliations

¹ Department of Surgery, University of Wisconsin Hospital and Clinics, 600 Highland Avenue K4/642, Madison, WI 53792, USA. Electronic address: https://twitter.com/LauraKrecko.
² Department of Surgery, University of Wisconsin Hospital and Clinics, 600 Highland Avenue K4/624, Madison, WI 53792, USA. Electronic address: https://twitter.com/mlautnermd.
³ Department of Surgery, University of Wisconsin Hospital and Clinics, 600 Highland Avenue K4/624, Madison, WI 53792, USA. Electronic address: wilke@surgery.wisc.edu.

PMID: 36410920
DOI: 10.1016/j.soc.2022.07.004

Abstract

Randomized controlled trials have informed the historical evolution of breast cancer management, distilling operative and nonoperative treatments to achieve disease control and improve survival while maximizing quality of life and minimizing complications. The authors describe landmark trials investigating and influencing the following aspects of breast cancer care: extent of breast surgery; axillary management; neoadjuvant and adjuvant therapies; and selection of chemotherapy versus endocrine therapy via application of genomic assays.

Keywords: Adjuvant; Axilla; Breast cancer; Chemotherapy; Clinical trials; Endocrine; Neoadjuvant.

Publication types

Review
Research Support, N.I.H., Extramural

MeSH terms

Axilla
Breast Neoplasms* / surgery
Female
Humans
Mastectomy
Neoadjuvant Therapy
Quality of Life

Grants and funding

T32 CA090217/CA/NCI NIH HHS/United States