Therapeutic strategies for intracerebral hemorrhage

Zhe Li; Suliman Khan; Yang Liu; Ruixue Wei; V Wee Yong; Mengzhou Xue

doi:10.3389/fneur.2022.1032343

Therapeutic strategies for intracerebral hemorrhage

Front Neurol. 2022 Nov 4:13:1032343. doi: 10.3389/fneur.2022.1032343. eCollection 2022.

Authors

Zhe Li^{1

2

3}, Suliman Khan^{1

2

3}, Yang Liu^{1

2

3}, Ruixue Wei^{1

2

3}, V Wee Yong⁴, Mengzhou Xue^{1

2

3}

Affiliations

¹ Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
² Academy of Medical Science, Zhengzhou University, Zhengzhou, China.
³ Henan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, China.
⁴ Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.

Abstract

Stroke is the second highest cause of death globally, with an increasing incidence in developing countries. Intracerebral hemorrhage (ICH) accounts for 10-15% of all strokes. ICH is associated with poor neurological outcomes and high mortality due to the combination of primary and secondary injury. Fortunately, experimental therapies are available that may improve functional outcomes in patients with ICH. These therapies targeting secondary brain injury have attracted substantial attention in their translational potential. Here, we summarize recent advances in therapeutic strategies and directions for ICH and discuss the barriers and issues that need to be overcome to improve ICH prognosis.

Keywords: intracerebral hemorrhage; neuroinflammation; neuronal death; secondary brain injury; therapeutic strategies.

Publication types

Review