No association of prion protein gene (PRNP) polymorphisms with susceptibility to the pandemic 2009 swine flu

Yong-Chan Kim; Sae-Young Won; Byung-Hoon Jeong

doi:10.1007/s13273-022-00318-x

No association of prion protein gene (PRNP) polymorphisms with susceptibility to the pandemic 2009 swine flu

Mol Cell Toxicol. 2022 Nov 12:1-5. doi: 10.1007/s13273-022-00318-x. Online ahead of print.

Authors

Yong-Chan Kim^{1

2}, Sae-Young Won^{1

2}, Byung-Hoon Jeong^{1

2}

Affiliations

¹ Korea Zoonosis Research Institute, Jeonbuk National University, 820-120, Hana-Ro, Iksan, Jeonbuk 54531 Republic of Korea.
² Department of Bioactive Material Sciences and Institute for Molecular Biology and Genetics, Jeonbuk National University, Jeonju, Jeonbuk 54896 Republic of Korea.

Abstract

Background: The pandemic 2009 swine flu is a highly infectious respiratory disorder caused by H1N1 influenza A viruses. A recent study reported that knockout of the prion protein gene (PRNP) induced susceptibility and lethality in influenza A virus-infected mice.

Objective: Thus, we examined the association between genetic variations of the PRNP gene and susceptibility to pandemic 2009 swine flu.

Results: We did not find an association between PRNP polymorphisms and susceptibility to pandemic 2009 swine flu.

Conclusions: To the best of our knowledge, this was the first evaluation of the association between PRNP polymorphisms and vulnerability to pandemic 2009 swine flu.

Keywords: H1N1; Influenza; PRNP; Pandemic; Prion disease; SNP; Susceptibility.

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