Analysis on internal mechanism of zedoary turmeric in treatment of liver cancer based on pharmacodynamic substances and pharmacodynamic groups

Zeyu Li; Erwei Hao; Rui Cao; Si Lin; Linghui Zou; Tianyan Huang; Zhengcai Du; Xiaotao Hou; Jiagang Deng

doi:10.1016/j.chmed.2022.06.007

Analysis on internal mechanism of zedoary turmeric in treatment of liver cancer based on pharmacodynamic substances and pharmacodynamic groups

Chin Herb Med. 2022 Sep 27;14(4):479-493. doi: 10.1016/j.chmed.2022.06.007. eCollection 2022 Oct.

Authors

Zeyu Li^{1

2

3}, Erwei Hao^{1

2

3}, Rui Cao^{1

2

3}, Si Lin^{1

2

3}, Linghui Zou^{1

2

3}, Tianyan Huang^{1

2

3}, Zhengcai Du^{1

2

3}, Xiaotao Hou^{1

2

3}, Jiagang Deng^{1

2

3}

Affiliations

¹ China ASEAN Joint Laboratory for International Cooperation in Traditional Medicine Research, Nanning 530200, China.
² Guangxi Scientific Experiment Center of Traditional Chinese Medicine, Nanning 530000, China.
³ Guangxi Key Laboratory of Pharmacodynamics of Traditional Chinese Medicine, Nanning 530000, China.

Abstract

Zedoary tumeric (Curcumae Rhizoma, Ezhu in Chinese) has a long history of application and has great potential in the treatment of liver cancer. The antiliver cancer effect of zedoary tumeric depends on the combined action of multiple pharmacodynamic substances. In order to clarify the specific mechanism of zedoary tumeric against liver cancer, this paper first analyzes the mechanism of its single pharmacodynamic substance against liver cancer, and then verifies the joint anti liver cancer mechanism of its "pharmacodynamic group". By searching the research on the antihepatoma effect of active components of zedoary tumeric in recent years, we found that pharmacodynamic substances, including curcumol, zedoarondiol, curcumenol, curzerenone, curdione, curcumin, germacrone, β-elemene, can act on multi-target and multi-channel to play an antihepatoma role. For example, curcumin can regulate miR, GLO1, CD133, VEGF, YAP, LIN28B, GPR81, HCAR-1, P53 and PI3K/Akt/mTOR, HSP70/TLR4 and NF-κB. Wnt/TGF/EMT, Nrf2/Keap1, JAK/STAT and other pathways play an antihepatoma role. Network pharmacological analysis showed that the core targets of the "pharmacodynamic group" for anti-life cancer are AKT1, EGFR, MAPK8, etc, and the core pathways are neuroactive live receiver interaction, nitrogen metabolism, HIF-1 signaling pathway, etc. At the same time, by comparing and analyzing the relationship between the specific mechanisms of pharmacodynamic substance and "pharmacodynamic group", it is found that they have great reference significance in target, pathway, biological function, determination of core pharmacodynamic components, formation of core target protein interaction, in-depth research of single pharmacodynamic substance, increasing curative effect and so on. By analyzing the internal mechanism of zedoary tumeric pharmacodynamic substance and "pharmacodynamic group" in the treatment of liver cancer, this paper intends to provide some ideas and references for the deeper pharmacological research of zedoary tumeric and the relationship between pharmacodynamic substance and "pharmacodynamic group".

Keywords: Curcumae Rhizoma; action mechanism; liver cancer; pharmacodynamic groups; pharmacodynamic substances; zedoary turmeric.

Publication types

Review