Coronavirus Disease-2019 and Implications on the Liver

Patrick T Campbell; Oren K Fix

doi:10.1016/j.cld.2022.08.003

Coronavirus Disease-2019 and Implications on the Liver

Clin Liver Dis. 2023 Feb;27(1):27-45. doi: 10.1016/j.cld.2022.08.003. Epub 2022 Aug 18.

Authors

Patrick T Campbell¹, Oren K Fix²

Affiliations

¹ Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Burnett-Womack Building, Campus Box 7584, Chapel Hill, NC 27599-7584, USA.
² Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Burnett-Womack Building, Campus Box 7584, Chapel Hill, NC 27599-7584, USA. Electronic address: oren.fix@unc.edu.

Abstract

The coronavirus disease-2019 (COVID-19) pandemic has had a large impact on patients with chronic liver disease (CLD) and liver transplantation (LT) recipients. Patients with advanced CLD are at a significantly increased risk of poor outcomes in the setting of severe acute respiratory syndrome coronavirus 2 infection. The pandemic has also considerably altered the management and care that is provided to patients with CLD, pre-LT patients, and LT recipients. Vaccination against COVID-19 protects patients with CLD and LT recipients from adverse outcomes and is safe in these patients; however, vaccine efficacy may be reduced in LT recipients and other immunosuppressed patients.

Keywords: Cirrhosis; Immunosuppression; SARS-CoV-2; Transplant; Vaccination.

Publication types

Review

MeSH terms

COVID-19*
Coronavirus*
Humans
Liver
Liver Transplantation* / adverse effects
Transplant Recipients