Three New Lanostanoids with Anti-HCV Effects from Abies nukiangensis

Yong-Li Li; Zhuo-Ni Xu; Jie Li; Shuang Liang; Min-Jie Xue; Jian-Jun Wu; Xian-Wen Yang

doi:10.1002/cbdv.202200941

Three New Lanostanoids with Anti-HCV Effects from Abies nukiangensis

Chem Biodivers. 2022 Dec;19(12):e202200941. doi: 10.1002/cbdv.202200941. Epub 2022 Nov 18.

Authors

Yong-Li Li¹, Zhuo-Ni Xu¹, Jie Li¹, Shuang Liang², Min-Jie Xue¹, Jian-Jun Wu¹, Xian-Wen Yang³

Affiliations

¹ Physical and Chemical Analysis laboratory, Shanghai Key laboratory of On-line Testing and Control Technology, Shanghai Institute of Measurement and Testing Technology, 1500 Zhangheng Road, Shanghai, 201203, China.
² Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
³ Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen, 361005, China.

PMID: 36398785
DOI: 10.1002/cbdv.202200941

Abstract

Three new lanostane derivatives (1-3) and twelve known triterpenoids (4-15) were isolated from the twigs and leaves of Abies nukiangensis. The structures of the new compounds were elucidated mainly by detailed analysis of their NMR and HR-ESI-MS spectroscopic data. Evaluation of the anti-HCV effects of all isolates showed that 3 exhibited moderate effect with the EC₅₀ value of 11.09 μM.

Keywords: Abies nukiangensis; Pinaceae; hepatitis C virus (HCV); lanostanoids; triterpenoids.

MeSH terms

Abies* / chemistry
Lanosterol
Magnetic Resonance Spectroscopy
Molecular Structure
Triterpenes* / chemistry
Triterpenes* / pharmacology

Substances

lanostanoid
Triterpenes
Lanosterol

Abstract

MeSH terms

Substances

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