LUBAC and NF-κB trigger a nuclear response from mitochondria

EMBO J. 2022 Dec 15;41(24):e112920. doi: 10.15252/embj.2022112920. Epub 2022 Nov 18.

Abstract

Mitochondria are key signaling hubs for innate immune responses. In this issue, Wu et al (2022) report that remodeling of the outer mitochondrial membrane by the linear ubiquiting chain assembly complex (LUBAC) facilitates transport of activated NF-κB to the nucleus in response to TNF signaling.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Mitochondria / metabolism
  • NF-kappa B* / metabolism
  • Signal Transduction
  • Ubiquitin-Protein Ligases* / metabolism
  • Ubiquitination

Substances

  • NF-kappa B
  • Ubiquitin-Protein Ligases

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