Homing in on homeostatic plasticity

Ruud F Toonen; Matthijs Verhage

doi:10.1016/j.neuron.2022.10.033

Homing in on homeostatic plasticity

Neuron. 2022 Nov 16;110(22):3645-3647. doi: 10.1016/j.neuron.2022.10.033.

Authors

Ruud F Toonen¹, Matthijs Verhage²

Affiliations

¹ Department of Functional Genomics, Center for Neurogenomics and Cognitive Research (CNCR), Amsterdam Neuroscience, VU University, Amsterdam, the Netherlands.
² Department of Functional Genomics, Center for Neurogenomics and Cognitive Research (CNCR), Amsterdam Neuroscience, VU University, Amsterdam, the Netherlands; Department of Clinical Genetics, Center for Neurogenomics and Cognitive Research (CNCR), Amsterdam Neuroscience, VU University Medical Center, Amsterdam, the Netherlands. Electronic address: matthijs@cncr.vu.nl.

PMID: 36395749
DOI: 10.1016/j.neuron.2022.10.033

Abstract

In this issue of Neuron, Orr et al.¹ demonstrate a detailed molecular cascade that drives presynaptic homeostatic plasticity and enhances presynaptic vesicle fusion in response to reduced postsynaptic activity. Two large presynaptic signaling complexes are central hubs.

Publication types

Comment

MeSH terms

Homeostasis / physiology
Neurons* / physiology
Signal Transduction* / physiology