Biomineralized hybrid nanodots for tumor therapy via NIR-II fluorescence and photothermal imaging

Xuegang Niu; Penghui Wei; Jiangnan Sun; Yuanxiang Lin; Xiaoyong Chen; Chenyu Ding; Yang Zhu; Dezhi Kang

doi:10.3389/fbioe.2022.1052014

Biomineralized hybrid nanodots for tumor therapy via NIR-II fluorescence and photothermal imaging

Front Bioeng Biotechnol. 2022 Oct 31:10:1052014. doi: 10.3389/fbioe.2022.1052014. eCollection 2022.

Authors

Xuegang Niu¹, Penghui Wei¹, Jiangnan Sun², Yuanxiang Lin¹, Xiaoyong Chen¹, Chenyu Ding¹, Yang Zhu³, Dezhi Kang¹

Affiliations

¹ Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
² Department of Psychology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
³ Department of Chemistry, University of Science and Technology of China, Hefei, China.

Abstract

Chemodynamic therapy (CDT) is an emerging and promising therapeutic strategy that suppresses tumor growth by catalytically converting intracellular hydrogen peroxide (H₂O₂) into highly-reactive hydroxyl radicals (•OH). However, the inherent substrate of H₂O₂ is relatively insufficient to achieve desirable CDT efficacy. Therefore, searching for integrated therapeutic methods with synergistic therapeutic modality is especially vital to augment therapeutic outcomes. Herein, we reported nanodot- Cu_xMn_yS_z @BSA@ICG (denoted as CMS@B@I) and bovine serum albumin (BSA)-based biomineralization Cu_xMn_yS_z (CMS) loaded with photodynamic agent-indocyanine green (ICG). CMS@B@I converts endogenous hydrogen peroxide (H₂O₂) into highly active hydroxyl radical (•OH) via Fenton reaction, and effectively produces reactive oxygen species (ROS) after being exposed to 808 nm laser irradiation, attributable to the excellent photodynamic agent-ICG. This results in eliciting a ROS storm. Additionally, CMS@B@I exhibits a superior photothermal effect under NIR-II 1064 nm laser irradiation to enhance tumor CDT efficacy. The NIR-II fluorescence imaging agent of ICG and the excellent photothermal effect of CMS@B@I are highly beneficial to NIR-II fluorescence and infrared thermal imaging, respectively, resulting in tracing the fate of CMS@B@I. This study attempts to design a bimodal imaging-guided and photothermal-enhanced CDT nanoagent for augmenting tumor catalytic therapy.

Keywords: NIR-II fluorescence imaging; chemodynamic therapy; photodynamic therapy; reactive oxygen species; tumor.