Circulatory microRNAs in helminthiases: Potent as diagnostics biomarker, its potential role and limitations

Hanif Ullah; Yali Tian; Safia Arbab; Ka Li; Muhammad Inayat Ullah Khan; Sajid Ur Rahman; Abdul Qadeer; Nehaz Muhammad; Suleman; Inam Ul Hassan

doi:10.3389/fvets.2022.1018872

Circulatory microRNAs in helminthiases: Potent as diagnostics biomarker, its potential role and limitations

Front Vet Sci. 2022 Oct 28:9:1018872. doi: 10.3389/fvets.2022.1018872. eCollection 2022.

Authors

Hanif Ullah¹, Yali Tian¹, Safia Arbab², Ka Li¹, Muhammad Inayat Ullah Khan³, Sajid Ur Rahman^{4

5}, Abdul Qadeer⁴, Nehaz Muhammad⁶, Suleman⁶, Inam Ul Hassan⁷

Affiliations

¹ West China School of Nursing/West China Hospital, Sichuan University, Chengdu, China.
² Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture, Key Laboratory of New Animal Drug Project of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou, China.
³ State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences, Wuhan, China.
⁴ Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.
⁵ Department of Food Science and Engineering, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
⁶ Department of Zoology, University of Swabi, Swabi, Pakistan.
⁷ Department of Microbiology, Hazara University Manshera, Manshera, Pakistan.

Abstract

Infections caused by helminths are responsible for severe public health problems and economic burden on continental scale. Well-timed and precise diagnosis of helminth infections is critical for taking by appropriate approaches for pathogen control. Circulating miRNAs are stable diagnostic tool for different diseases found in a variety of body fluid. As diagnostic biomarkers in infectious diseases, miRNAs detection in body fluids of helminth infected hosts is growing promptly. Uncovering miRNAs is a relatively new tool, used for early-stage detection of helminth infection from experimental or non-invasive clinical samples. miRNAs can be detected in body fluids such as serum, saliva, urine, and tissues of helminth infected host, mainly blood offering important benefits for diagnosis accurately. In this review, we discuss different characteristics of helminth parasite-derived circulating and EV miRNAs, supporting its potential uses in for helminth diagnosis and treatment efficiency.

Keywords: biomarker; circulatory microRNAs; diagnosis; helminths; vesicle.

Publication types

Review