A case report of primary cardiac angiosarcoma with DNMT3A gene mutation

Kun Tian; Yating Liu; Haiying Zhu; Tao Wang; Tianxing Chen; Xiaxia Pei; Feixue Song

doi:10.3389/fonc.2022.1018741

A case report of primary cardiac angiosarcoma with DNMT3A gene mutation

Front Oncol. 2022 Oct 27:12:1018741. doi: 10.3389/fonc.2022.1018741. eCollection 2022.

Authors

Kun Tian¹, Yating Liu¹, Haiying Zhu¹, Tao Wang¹, Tianxing Chen¹, Xiaxia Pei¹, Feixue Song¹

Affiliation

¹ Department of Medical Oncology, Second Hospital of Lanzhou University, Lanzhou, China.

Abstract

Cardiac angiosarcoma is a rare disease with a high mortality rate despite its low incidence. Surgery is currently the mainstay treatment strategy for patients with this condition. Herein, we describe a case of primary cardiac angiosarcoma, including symptoms, examination findings, treatment strategy and prognosis. In 2020, the patient was admitted to our hospital, and Next-Generation Sequencing (NGS) revealed a mutation in the DNMT3A gene. Generally, DNMT3A mutations are most commonly seen in atherosclerosis and myeloid leukemia. To our knowledge, this is the first reported case of primary cardiac angiosarcoma with DNMT3A gene mutation.

Keywords: DNMT3A; cardiac angiosarcoma; cardiac tumor rupture; chemotherapy; surgery.

Publication types

Case Reports