The regulation of antiviral activity of interferon epsilon

Fu-Rong Zhao; Wei Wang; Qin Zheng; Yan-Ge Zhang; Jianming Chen

doi:10.3389/fmicb.2022.1006481

The regulation of antiviral activity of interferon epsilon

Front Microbiol. 2022 Oct 25:13:1006481. doi: 10.3389/fmicb.2022.1006481. eCollection 2022.

Authors

Fu-Rong Zhao^{1

2}, Wei Wang¹, Qin Zheng¹, Yan-Ge Zhang¹, Jianming Chen¹

Affiliations

¹ Fujian Key Laboratory on Conservation and Sustainable Utilization of Marine Biodiversity, Fuzhou Institute of Oceanography, Minjiang University, Fuzhou, China.
² Fujian Provincial Key Laboratory for Prevention and Control of Animal Infectious Diseases and Biotechnology, Longyan University, Longyan, China.

Abstract

Interferon epsilon (IFN-ε) is a type I IFN. Some biological properties has been identified in many species, such as antiproliferative, anti-tumor, and antiviral effects, of IFN-ε, which are much weaker than those of IFN-α, have also been revealed. It has been shown to play a role in mucosal immunity and bacterial infection and in the prevention of certain sexually transmitted diseases, such as human immunodeficiency virus (HIV). This paper reviews the known activity of IFN-ε, particularly in some viruses. In general, this review provides a better understanding of effective IFN-ε treatment in the future.

Keywords: antiviral; biological activities; interferon epsilon; type I IFNs; viral interference.

Publication types

Review