Salvianolic acid B from Salvia miltiorrhiza bunge: A potential antitumor agent

Sha-Sha Guo; Zhen-Guo Wang

doi:10.3389/fphar.2022.1042745

Salvianolic acid B from Salvia miltiorrhiza bunge: A potential antitumor agent

Front Pharmacol. 2022 Oct 25:13:1042745. doi: 10.3389/fphar.2022.1042745. eCollection 2022.

Authors

Sha-Sha Guo^{1

2}, Zhen-Guo Wang^{1

2}

Affiliations

¹ Key Laboratory of Theory of TCM, Ministry of Education of China, Shandong University of Traditional Chinese Medicine, Jinan, China.
² Institute of Traditional Chinese Medicine Literature and Culture, Shandong University of Traditional Chinese Medicine, Jinan, China.

Abstract

Salvia miltiorrhiza Bunge (Lamiaceae) is a perennial herb widely found in China since ancient times with a high economic and medicinal value. Salvianolic acid B (Sal-B) is an important natural product derived from Salvia miltiorrhiza and this review summarizes the anticancer activity of Sal-B. Sal-B inhibits tumor growth and metastasis by targeting multiple cell signaling pathways. This review aims to review experimental studies to describe the possible anticancer mechanisms of Sal-B and confirm its potential as a therapeutic drug.

Keywords: TCM; anticancer activity; apoptosis; mechanism; salvianolic acid B; traditional Chinese medicine.

Publication types

Review