Letting go: Dishevelled phase separation recruits Axin to stabilize β-catenin

J Cell Biol. 2022 Dec 5;221(12):e202211001. doi: 10.1083/jcb.202211001. Epub 2022 Nov 16.

Abstract

Dishevelled exerts a molecular force that guides cell fate, but how it does so remains enigmatic. In this issue, Kang et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202205069) show Dvl2 undergoes liquid-liquid phase separation to stabilize β-catenin by pulling Axin into its biomolecular condensate at the plasma membrane.

Publication types

  • Comment

MeSH terms

  • Axin Protein* / genetics
  • Axin Protein* / metabolism
  • Axin Signaling Complex
  • Dishevelled Proteins* / genetics
  • Dishevelled Proteins* / metabolism
  • Humans
  • Wnt Signaling Pathway
  • beta Catenin* / genetics
  • beta Catenin* / metabolism

Substances

  • Axin Protein
  • beta Catenin
  • Dishevelled Proteins
  • Axin Signaling Complex