Monocytes: A Promising New TRAIL in Ovarian Cancer Cell Therapy

Clin Cancer Res. 2023 Jan 17;29(2):299-301. doi: 10.1158/1078-0432.CCR-22-2877.

Abstract

Adoptive cell transfer of IFN-activated monocytes administered intraperitoneally to patients with platinum-resistant ovarian cancer demonstrated antitumor effects and acceptable tolerability. The exposure of monocytes to IFNα and IFNγ upregulated TRAIL, which triggered caspase 8 and direct cell-to-cell contact-dependent apoptosis of ovarian cancer cells. See related article by Green et al., p. 349.

Publication types

  • Comment

MeSH terms

  • Apoptosis
  • Apoptosis Regulatory Proteins
  • Cell Line, Tumor
  • Female
  • Humans
  • Interferon-alpha
  • Monocytes* / pathology
  • Ovarian Neoplasms* / pathology
  • Ovarian Neoplasms* / therapy
  • TNF-Related Apoptosis-Inducing Ligand / genetics
  • Tumor Necrosis Factor-alpha

Substances

  • Apoptosis Regulatory Proteins
  • Interferon-alpha
  • TNF-Related Apoptosis-Inducing Ligand
  • Tumor Necrosis Factor-alpha
  • TNFSF10 protein, human