Development of novel antibacterial strategies is required to tackle the alarming threat for global health due to antimicrobial resistance. In this issue of the Journal of Bacteriology, Boulanger et al. provide evidence supporting that the blocking of metabolic pathways to induce accumulation of toxic intermediates can be a possible approach to combat bacterial infections (E. F. Boulanger, A. Sabag-Daigle, M. Baniasad, K. Kokkinias, et al., J Bacteriol 204:e00344-22, 2022, https://doi.org/10.1128/jb.00344-22).
Keywords: Salmonella; antibacterial; antibiotic resistance; autointoxication; metabolite; sugar-phosphate; toxicity; virulence.