A genomic deep field view of hypertension

Pranav S Garimella; Clea du Toit; Nhu Ngoc Le; Sandosh Padmanabhan

doi:10.1016/j.kint.2022.09.029

A genomic deep field view of hypertension

Kidney Int. 2023 Jan;103(1):42-52. doi: 10.1016/j.kint.2022.09.029. Epub 2022 Oct 29.

Authors

Pranav S Garimella¹, Clea du Toit², Nhu Ngoc Le², Sandosh Padmanabhan³

Affiliations

¹ Division of Nephrology and Hypertension, University of California San Diego, San Diego, California, USA.
² School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
³ School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK. Electronic address: Sandosh.Padmanabhan@glasgow.ac.uk.

PMID: 36377113
DOI: 10.1016/j.kint.2022.09.029

Abstract

Blood pressure is regulated by a complex neurohumoral system including the renin-angiotensin-aldosterone system, natriuretic peptides, endothelial pathways, the sympathetic nervous system, and the immune system. This review charts the evolution of our understanding of the genomic basis of hypertension at increasing resolution over the last 5 decades from monogenic causes to polygenic associations, spanning ∼30 monogenic rare variants and >1500 single nucleotide variants. Unexpected early wins from blood pressure genomics include deepening of our understanding of the complex causation of hypertension; refinement of causal estimates bidirectionally between blood pressure, risk factors, and outcomes through Mendelian randomization; risk stratification using polygenic risk scores; and opportunities for precision medicine and drug repurposing.

Keywords: GWAS; blood pressure; genetics; hypertension; kidneys; sodium; vascular disorder.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Blood Pressure / genetics
Genomics
Humans
Hypertension*
Renin-Angiotensin System / genetics
Risk Factors

Abstract

Publication types

MeSH terms

Grants and funding