Comparative Sedation with Sevoflurane and Thiopental in Children Undergoing MR Imaging

J Coll Physicians Surg Pak. 2022 Nov;32(11):1381-1385. doi: 10.29271/jcpsp.2022.11.1381.

Abstract

Objective: To compare the use of propofol and thiopental in children undergoing MRI.

Study design: Descriptive, comparative study.

Place and duration of study: University of Health Sciences, Van Training and Research Hospital, Van, Turkey, between January 01 and December 31, 2019.

Methodology: One thousand two hundred and twenty two paediatric patients having MRI were included and divided into two groups. Patients aged 2-18 years who were administered Propofol were classified as Group I, and the patients under the age of 2 years who were administered Thiopental were classified as group II. All patients received Sevoflurane insufflation via face mask after induction agent. Patient's demographic data, ASA scores, anaesthesia-procedure-recovery times, comorbidities, type of MRI examination and complications were recorded.

Results: Age, body weight and ASA score of the patients in Group I were higher than Group II (p<0.05). Epilepsy, cerebral palsy, mental retardation, speech retardation and autism were more prevalent in Group I than in Group II (p<0.05). Neuromuscular growth retardation, hydrocephalus, and metabolic disease were less common in Group I than in Group II (p<0.05). With this Apnea and desaturation was higher in Group I, and bradycardia was higher in Group II.

Conclusion: Sevoflurane insufflation with a face mask can be safely used in children after induction of anaesthesia with propofol or thiopental.

Key words: Sedation, Paediatric patients, Propofol, Thiopental, Sevoflurane.

MeSH terms

  • Anesthesia Recovery Period
  • Anesthesia*
  • Anesthetics, Inhalation* / adverse effects
  • Anesthetics, Intravenous
  • Child
  • Humans
  • Magnetic Resonance Imaging / methods
  • Methyl Ethers*
  • Propofol* / adverse effects
  • Sevoflurane
  • Thiopental

Substances

  • Thiopental
  • Sevoflurane
  • Propofol
  • Methyl Ethers
  • Anesthetics, Inhalation
  • Anesthetics, Intravenous