Diagnosis and treatment of vascular graft and endograft infections: a structured clinical approach

Marjan Wouthuyzen-Bakker; Marleen van Oosten; Wouter Bierman; Rik Winter; Andor Glaudemans; Riemer Slart; Marlous Toren-Wielema; Ignace Tielliu; Clark J Zeebregts; Niek H J Prakken; Jean Paul de Vries; Ben R Saleem

doi:10.1016/j.ijid.2022.11.011

Diagnosis and treatment of vascular graft and endograft infections: a structured clinical approach

Int J Infect Dis. 2023 Jan:126:22-27. doi: 10.1016/j.ijid.2022.11.011. Epub 2022 Nov 11.

Authors

Affiliations

¹ Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. Electronic address: m.wouthuyzen-bakker@umcg.nl.
² Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
³ Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
⁴ Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
⁵ Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
⁶ Division of Vascular Surgery, Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
⁷ Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

PMID: 36375692
DOI: 10.1016/j.ijid.2022.11.011

Abstract

A vascular graft or endograft infection (VGEI) is a severe complication that can occur after vascular graft or endograft surgery and is associated with high morbidity and mortality rates. A multidisciplinary approach, consisting of a team of vascular surgeons, infectious diseases specialists, medical microbiologists, radiologists, nuclear medicine specialists, and hospital pharmacists, is needed to adequately diagnose and treat VGEI. A structured diagnostic, antibiotic, and surgical treatment algorithm helps clinical decision making and ultimately aims to improve the clinical outcome of patients with a VGEI.

Keywords: Antibiotic treatment; Diagnosis; Endograft infection; Surgical treatment; Vascular graft infection.

MeSH terms

Blood Vessel Prosthesis / adverse effects
Blood Vessel Prosthesis Implantation* / adverse effects
Endovascular Procedures* / adverse effects
Humans
Prosthesis-Related Infections* / diagnosis
Prosthesis-Related Infections* / drug therapy
Prosthesis-Related Infections* / surgery
Treatment Outcome
Vascular Diseases* / etiology
Vascular Grafting*