Exosomes in HBV infection

Ziyu Liu; Yanan Li; Yufeng Wang; Xinquan Bai; Ying Zhang

doi:10.1016/j.cca.2022.11.012

Exosomes in HBV infection

Clin Chim Acta. 2023 Jan 1:538:65-69. doi: 10.1016/j.cca.2022.11.012. Epub 2022 Nov 12.

Authors

Ziyu Liu¹, Yanan Li², Yufeng Wang³, Xinquan Bai², Ying Zhang⁴

Affiliations

¹ Pediatric Respiratory Department, First Hospital of Jilin University, Changchun, Jilin 130021, China; School of Life Science, Jilin University, Changchun, Jilin 130021, China.
² Pediatric Respiratory Department, First Hospital of Jilin University, Changchun, Jilin 130021, China.
³ First School of Clinical Medicine, Jilin University, Changchun, Jilin 130021, China.
⁴ Pediatric Respiratory Department, First Hospital of Jilin University, Changchun, Jilin 130021, China. Electronic address: yingzhang@jlu.edu.cn.

PMID: 36375524
DOI: 10.1016/j.cca.2022.11.012

Abstract

Exosomes have been identified as important mediators of intercellular communication in several physiological and pathological processes. Hepatitis B is caused by infection with the hepatitis B virus (HBV), which impairs hepatocytes, with chronic infection resulting in cirrhosis or liver cancer. We studied the roles and functions of exosomes in HBV infection and found that exosomes could promote HBV spread and development of HBV-related diseases. Exosomes could be used as potential biomarkers for HBV diagnosis. Furthermore, exosomes have potential applications in treatment for HBV infection via inhibition of HBV replication and transcription.

Keywords: Exosome; HBV; Replication; Synthesis; Therapeutic target.

Publication types

Review

MeSH terms

Exosomes*
Hepatitis B virus / physiology
Hepatitis B*
Hepatitis B, Chronic*
Hepatocytes
Humans
Liver Neoplasms*
Virus Replication