Early Development of Innate Lymphoid Cells

Yi Ding; Christelle Harly; Arundhoti Das; Avinash Bhandoola

doi:10.1007/978-1-0716-2740-2_3

Early Development of Innate Lymphoid Cells

Methods Mol Biol. 2023:2580:51-69. doi: 10.1007/978-1-0716-2740-2_3.

Authors

Yi Ding¹, Christelle Harly², Arundhoti Das³, Avinash Bhandoola⁴

Affiliations

¹ T Cell Biology and Development Unit, Laboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institute of Health, Bethesda, MD, USA. dingy3@nih.gov.
² Université de Nantes, CNRS, Inserm, CRCINA, Nantes, France.
³ T Cell Biology and Development Unit, Laboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institute of Health, Bethesda, MD, USA.
⁴ T Cell Biology and Development Unit, Laboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institute of Health, Bethesda, MD, USA. avinash.bhandoola@nih.gov.

PMID: 36374450
DOI: 10.1007/978-1-0716-2740-2_3

Abstract

Innate lymphoid cells (ILCs) are transcriptionally and functionally similar to T cells but lack adaptive antigen receptors. They play critical roles in early defense against pathogens. In this review, we summarize recent discoveries of ILC progenitors and discuss possible mechanisms that separate ILCs from T cells. We consider mechanisms of lineage specification in early ILC development and also examine whether differences exist between adult and fetal ILC development.

Keywords: EILP; ILC; ILCP; Innate lymphoid cells; Lineage specification; NK cells.

Publication types

Review

MeSH terms

Immunity, Innate*
Lymphocytes*
T-Lymphocytes