Xenotransplantation and Risks: The Opinion of Veterinary Students at Spanish Universities

Transplant Proc. 2022 Nov;54(9):2411-2413. doi: 10.1016/j.transproceed.2022.10.034. Epub 2022 Nov 11.

Abstract

Background: Understanding the perception of the risks associated with xenotransplant, especially among professionals who will contribute to the care of the animals, is important for xenotransplant to become a clinical reality. The objective of this study was to analyze opinions regarding the risks of organ xenotransplant among veterinary university students in Spain.

Methods: The study population was 2683 veterinary students from different courses and universities in Spain. Instrument valuation: Validated self-administered questionnaire completed anonymously (PCID-XENOTx-Ríos). Consent to collaborate in the study was requested. Variables for the study: attitude toward xenotransplant and risks (infectious, immunologic, ethical/moral, philosophical, religious, other unspecified risks).

Statistics: descriptive analysis, Student t test, χ2 test, and Fisher exact test.

Results: Of the total number of respondents, 2646 students answered this question, with a completion rate of 98.6%. They considered immunologic risk 78.4% (n = 2074), infectious risk 48.6% (n = 1286), ethical/moral risk 10.7% (n = 284), philosophical risk 5.2% (n = 137), religious risk 1.5% (n = 40), and other risks 3.9% (n = 104). Significant relationships were observed between immunologic risks (P < .001), ethical/moral risks (P < .001), and other risks (P = .002).

Conclusions: Despite the consideration of different types of risks, the favorable attitude toward xenotransplant among veterinary students at Spanish universities is highly prevalent, and evidence-based information campaigns on the different risks associated with xenotransplant are important.

MeSH terms

  • Animals
  • Attitude
  • Health Knowledge, Attitudes, Practice
  • Humans
  • Organ Transplantation*
  • Spain
  • Students
  • Surveys and Questionnaires
  • Tissue and Organ Procurement*
  • Transplantation, Heterologous / adverse effects
  • Universities