Lanthanum-based metal organic framework (La-MOF) use of 3,4-dihydroxycinnamic acid as drug delivery system linkers in human breast cancer therapy

Moosareza Safinejad; Amir Rigi; Malihe Zeraati; Zohreh Heidary; Shohreh Jahani; Narendra Pal Singh Chauhan; Ghasem Sargazi

doi:10.1186/s13065-022-00886-y

Lanthanum-based metal organic framework (La-MOF) use of 3,4-dihydroxycinnamic acid as drug delivery system linkers in human breast cancer therapy

BMC Chem. 2022 Nov 12;16(1):93. doi: 10.1186/s13065-022-00886-y.

Authors

Moosareza Safinejad¹, Amir Rigi², Malihe Zeraati³, Zohreh Heidary⁴, Shohreh Jahani⁵, Narendra Pal Singh Chauhan⁶, Ghasem Sargazi⁷

Affiliations

¹ RF MEMS & Micro Bio-Nano Electronics (MBNE) Lab, Department of Electrical Engineering, Shahid Bahonar University of Kerman, Kerman, Iran.
² Department of Nursing, Young Researchers and Elite Club, Zahedan Branch, Islamic Azad University, Zahedan, Iran.
³ Department of Materials Engineering, Shahid Bahonar University of Kerman, Kerman, 761694111, Iran.
⁴ Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
⁵ Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran.
⁶ Department of Chemistry, Bhupal Nobles' University, Udaipur-313002, Rajasthan, India.
⁷ Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran. g.sargazi@gmail.com.

Abstract

Metal organic frameworks (MOFs) have received a lot of attention in the research community due to their unique physical properties, which make them ideal materials for targeted drug delivery systems. In this paper, we describe the synthesis of a non-toxic La-based MOF with 3,4-dihydroxycinnamic acid (3,4-DHCA) as a linker. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive spectroscopy (EDS), fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), nitrogen adsorption-desorption measurements, and X-ray powder diffraction (XRD) have all been used to characterize it thoroughly. The La-based MOF showed good biocompatibility with the human breast cancer cell line MDA-MB-468. The ability of 3,4-DHCA to treat MDA-MB-468 cells was confirmed by 40.35% cell viability with La-based MOF. Based on the findings, La-based MOF can be recommended as a promising candidate for anticancer delivery.

Keywords: Anticancer; Characterization; Drug delivery; Linker; Metal organic framework; Synthesis.