Structures of SARS-CoV-2 spike protein alert noteworthy sites for the potential approaching variants

Xiaorui Xing; Lei Wang; Zhen Cui; Wangjun Fu; Tao Zheng; Lili Qin; Pingju Ge; Aidong Qian; Nan Wang; Shuai Yuan

doi:10.1016/j.virs.2022.11.003

Structures of SARS-CoV-2 spike protein alert noteworthy sites for the potential approaching variants

Virol Sin. 2022 Dec;37(6):938-941. doi: 10.1016/j.virs.2022.11.003. Epub 2022 Nov 8.

Authors

Xiaorui Xing¹, Lei Wang², Zhen Cui², Wangjun Fu², Tao Zheng², Lili Qin³, Pingju Ge³, Aidong Qian⁴, Nan Wang⁵, Shuai Yuan⁶

Affiliations

¹ College of Veterinary Medicine, Jilin Agricultural University, Changchun, 130118, China; College of Animal Science and Technology, Jilin Provincial Engineering Research Center of Animal Probiotics, Key Lab of Animal Production, Product Quality and Security, Joint Laboratory of Modern Agricultural Technology International Cooperation, Ministry of Education, Jilin Agricultural University, Changchun, 130118, China; CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
² CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China; University of Chinese Academy of Sciences, Beijing, 100101, China.
³ Acrobiosystems, Beijing, 100101, China.
⁴ College of Veterinary Medicine, Jilin Agricultural University, Changchun, 130118, China; College of Animal Science and Technology, Jilin Provincial Engineering Research Center of Animal Probiotics, Key Lab of Animal Production, Product Quality and Security, Joint Laboratory of Modern Agricultural Technology International Cooperation, Ministry of Education, Jilin Agricultural University, Changchun, 130118, China. Electronic address: qianaidong0115@163.com.
⁵ CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. Electronic address: wangnan161@ibp.ac.cn.
⁶ State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China. Electronic address: yuanshuai@wh.iov.cn.

Abstract

•
Deletion of residues 156–157 warps the neighboring beta-sheet and leads NTD and RBD to shift.
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T859N stabilizes the packing of the 630 loop motif to make RBD standing transition more difficult.
•
The overall structures of the closed state S complex from different variants resemble each other.
•
Mutations in FPPR may affect the overall structure of the trimeric spike protein.

Publication types

Letter

MeSH terms

COVID-19*
Humans
Mutation
SARS-CoV-2
Spike Glycoprotein, Coronavirus

Substances

spike protein, SARS-CoV-2
Spike Glycoprotein, Coronavirus