Understanding inter-individual variability in short-chain chlorinated paraffin concentrations in human blood

Shan Niu; Xi Chen; Ruiwen Chen; Yun Zou; ZhiZhen Zhang; Li Li; Kimberly J Hageman; Carla Ng; Liang Dong

doi:10.1016/j.jhazmat.2022.130235

Understanding inter-individual variability in short-chain chlorinated paraffin concentrations in human blood

J Hazard Mater. 2023 Feb 5;443(Pt B):130235. doi: 10.1016/j.jhazmat.2022.130235. Epub 2022 Oct 28.

Authors

Shan Niu¹, Xi Chen², Ruiwen Chen³, Yun Zou⁴, ZhiZhen Zhang⁵, Li Li⁵, Kimberly J Hageman⁶, Carla Ng⁷, Liang Dong⁸

Affiliations

¹ Department of Civil & Environmental Engineering, University of Pittsburgh, Pittsburgh, PA, USA; National Research Center for Environmental Analysis and Measurement, Beijing, Beijing, China. Electronic address: shan.niu@pitt.edu.
² National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China.
³ Department of Civil & Environmental Engineering, University of Pittsburgh, Pittsburgh, PA, USA.
⁴ Organic Biological Analytical Chemistry Group, Department of Chemistry, University of Liège, Liège, Belgium.
⁵ School of Public Health, University of Nevada, Reno, NV, USA.
⁶ Department of Chemistry & Biochemistry, Utah State University, Logan, UT, USA.
⁷ Department of Civil & Environmental Engineering, University of Pittsburgh, Pittsburgh, PA, USA; Department of Environmental & Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA.
⁸ National Research Center for Environmental Analysis and Measurement, Beijing, Beijing, China.

PMID: 36368064
DOI: 10.1016/j.jhazmat.2022.130235

Abstract

Chlorinated paraffins (CPs), particularly short-chain CPs (SCCPs), have been reported in human blood with high detection frequency and often high variation among individuals. However, factors associated with and their contributions to inter-individual variability in SCCP concentrations in human blood have not been assessed. In this study, we first measured SCCP concentrations in 57 human blood samples collected from individuals living in the same vicinity in China. We then used the PROduction-To-Exposure model to investigate the impacts of variations in sociodemographic data, biotransformation rates, dietary patterns, and indoor contamination on inter-individual variability in SCCP concentrations in human blood. Measured ∑SCCP concentrations varied by a factor of 10 among individuals with values ranging from 122 to 1230 ng/g, wet weight. Model results show that age, sex, body weight, and dietary composition played a minor role in causing variability in ∑SCCP concentrations in human blood given that modeled ∑SCCP concentrations ranged over a factor of 2 - 3 correlated to the variations of these factors. In contrast, variations in the modeled ΣSCCP concentrations increased to factors of 6 and 8 when variability in biotransformation rates and indoor contamination were considered, respectively, indicating these two factors could be the most influential on inter-individual variability in SCCP concentrations in human blood.

Keywords: Biomonitoring of SCCPs; Biotransformation; Human exposure; Indoor contamination; PROTEX model.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

China
Environmental Monitoring / methods
Humans
Hydrocarbons, Chlorinated* / analysis
Paraffin* / analysis

Substances

Paraffin
Hydrocarbons, Chlorinated