Deep Eutectic Systems as Novel Vehicles for Assisting Drug Transdermal Delivery

Jinbao Wang; Mingjian Li; Langhuan Duan; Yameng Lin; Xiuming Cui; Ye Yang; Chengxiao Wang

doi:10.3390/pharmaceutics14112265

Deep Eutectic Systems as Novel Vehicles for Assisting Drug Transdermal Delivery

Pharmaceutics. 2022 Oct 23;14(11):2265. doi: 10.3390/pharmaceutics14112265.

Authors

Jinbao Wang^{1

2}, Mingjian Li^{1

2}, Langhuan Duan^{1

2}, Yameng Lin^{1

2}, Xiuming Cui^{1

2}, Ye Yang^{1

2}, Chengxiao Wang^{1

2}

Affiliations

¹ School of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
² State Key Laboratory of Geological Processes and Mineral Resources, China University of Geosciences, Wuhan 430074, China.

Abstract

In recent years, deep eutectic systems (DES) emerged as novel vehicles for facilitating the transdermal delivery of various drugs, including polysaccharides, proteins, insulin, vaccine, nanoparticles, and herb extracts. The objective of this study is to conduct a comprehensive review of the application of DES to transdermal drug delivery, based on previous work and the reported references. Following a brief overview, the roles of DES in TDDS, the modes of action, as well as the structure-activity relationship of DES are discussed. Particularly, the skin permeation of active macromolecules and rigid nanoparticles, which are the defining characteristics of DES, are extensively discussed. The objective is to provide a comprehensive understanding of the current investigation and development of DES-based transdermal delivery systems, as well as a framework for the construction of novel DES-TDDS in the future.

Keywords: deep eutectic solvent; penetration enhancer; permeability; solubility; transdermal drug delivery system.

Publication types

Review

Grants and funding

This work was supported by the National Natural Science Foundation of China (81760642; 82060645 and 82260698), the Key Natural Science Foundation of Yunnan Province (202101AT070099), the Key R&D Project of Yunnan Provincial Science and Technology Department (202003AC100013).