Complex-Forming Properties of Ceftazidime with Fe(III) Ions in an Aqueous Solution

Marek Pająk; Magdalena Woźniczka; Jakub Fichna

doi:10.3390/molecules27217226

Complex-Forming Properties of Ceftazidime with Fe(III) Ions in an Aqueous Solution

Molecules. 2022 Oct 25;27(21):7226. doi: 10.3390/molecules27217226.

Authors

Marek Pająk¹, Magdalena Woźniczka¹, Jakub Fichna²

Affiliations

¹ Department of Physical and Biocoordination Chemistry, Medical University of Lodz, Muszyńskiego 1, 90-151 Lodz, Poland.
² Department of Biochemistry, Medical University of Lodz, Mazowiecka 5, 92-215 Lodz, Poland.

Abstract

In the present study, the complexing properties of ceftazidime with Fe(III) ions in aqueous solutions were characterized by UV-vis spectrophotometric and potentiometric methods. Using the UV-vis spectrophotometric method, the absorbance values for Fe(III) ions, a third-generation cephalosporin antibiotic (ceftazidime), and the Fe(III)-ceftazidime system were determined. Based on pH-metric studies, the value of the stability constant for the Fe(III)-ceftazidime complex was calculated.

Keywords: Fe(III) complexes; UV-vis spectroscopy; ceftazidime; potentiometry.

MeSH terms

Ceftazidime*
Ferric Compounds*
Ions
Potentiometry
Water

Substances

Ferric Compounds
Ceftazidime
Ions
Water

Grants and funding

Financial support of this work by the Medical University of Lodz (Statutory Fund No. 503/3-014-02/503-31-001–Mirosława Świątek; Statutory Fund No. 503/1-156-04/503-11-001-19–Jakub Fichna) is gratefully acknowledged.