Recent Advances of Silver-Based Coordination Polymers on Antibacterial Applications

Wenfeng Zhang; Gaomin Ye; Donghui Liao; Xuelin Chen; Chengyu Lu; Alireza Nezamzadeh-Ejhieh; M Shahnawaz Khan; Jianqiang Liu; Ying Pan; Zhong Dai

doi:10.3390/molecules27217166

Recent Advances of Silver-Based Coordination Polymers on Antibacterial Applications

Molecules. 2022 Oct 23;27(21):7166. doi: 10.3390/molecules27217166.

Authors

Wenfeng Zhang^{1

2}, Gaomin Ye^{1

2}, Donghui Liao^{1

2}, Xuelin Chen¹, Chengyu Lu¹, Alireza Nezamzadeh-Ejhieh³, M Shahnawaz Khan⁴, Jianqiang Liu¹, Ying Pan^{1

2}, Zhong Dai¹

Affiliations

¹ Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs, School of Pharmacy, Guangdong Medical University Key Laboratory of Research and Development of New Medical Materials, Guangdong Medical University, Dongguan 523808, China.
² The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, China.
³ Chemistry Department, Shahreza Branch, Islamic Azad University, Shahreza 311-86145, Iran.
⁴ Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India.

Abstract

With the continuous evolution of bacteria and the constant use of traditional antibiotics, the emergence of drug-resistant bacteria and super viruses has attracted worldwide attention. Antimicrobial therapy has become the most popular and important research field at present. Coordination Polymer (CP) and/or metal-organic framework (MOF) platforms have the advantages of a high biocompatibility, biodegradability, and non-toxicity, have a great antibacterial potential and have been widely used in antibacterial treatment. This paper reviewed the mechanism and antibacterial effect of three typical MOFs (pure Ag-MOFs, hybrid Ag-MOFs, and Ag-containing-polymer @MOFs) in silver-based coordination polymers. At the same time, the existing shortcomings and future views are briefly discussed. The study on the antibacterial efficacy and mechanism of Ag-MOFs can provide a better basis for its clinical application and, meanwhile, open up a novel strategy for the preparation of more advanced Ag-contained materials with antibacterial characteristics.

Keywords: anti-bacterial effect; anti-bacterial mechanism; metal-organic frameworks; silver.

Publication types

Review

MeSH terms

Anti-Bacterial Agents / pharmacology
Metal-Organic Frameworks* / pharmacology
Polymers / pharmacology
Silver* / pharmacology

Substances

Silver
Polymers
Anti-Bacterial Agents
Metal-Organic Frameworks

Grants and funding

This research was partially funded by the Guangdong Basic and Applied Basic Research Foundation (2019A1515110260), Guangdong Basic and Applied Basic Research Foundation (2021A1515011616), scientific research project of Traditional Chinese Medicine Bureau of Guangdong Province (20211227), Featured Innovation Project of Guangdong Province (2019KTSCX052 and 2019KTSCX053), and key scientific research project of Colleges and Universities of Education Department of Guangdong Province (20202ZDZX2046 and 2021ZDZX2052), and the Panfeng 100 Joint Training Program of Guangdong Medical University (PF100-1-03), Guangdong Medical University Research Project (4SG22265P) and Guangdong Province Universities and Colleges Pearl River Scholar Fund (No. 4SG22006G), and Special Funds for Scientific Technological Innovation of Undergraduates in Guangdong Province (pdjh2021b0227, pdjh2021a0218, pdjh2022a0216, pdjh2022b0225 and pdjh20220224). M.S.K. thanks ICMR New Delhi, India, for a Senior Research Fellowship.