Bio-Multifunctional Sponges Containing Alginate/Chitosan/Sargassum Polysaccharides Promote the Healing of Full-Thickness Wounds

Weiyan Quan; Puwang Li; Jinsong Wei; Yuwei Jiang; Yingye Liang; Weilin Zhang; Qizhou Chen; Kefeng Wu; Hui Luo; Qianqian Ouyang

doi:10.3390/biom12111601

Bio-Multifunctional Sponges Containing Alginate/Chitosan/Sargassum Polysaccharides Promote the Healing of Full-Thickness Wounds

Biomolecules. 2022 Oct 31;12(11):1601. doi: 10.3390/biom12111601.

Authors

Weiyan Quan¹, Puwang Li², Jinsong Wei³, Yuwei Jiang¹, Yingye Liang¹, Weilin Zhang³, Qizhou Chen¹, Kefeng Wu^{1

4}, Hui Luo^{1

4}, Qianqian Ouyang^{1

4}

Affiliations

¹ The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang 524023, China.
² South Subtropical Crop Research Institute, China Academy of Tropical Agricultural Sciences, Zhanjiang 524023, China.
³ Orthopaedic Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China.
⁴ The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang 524023, China.

Abstract

Creation of bio-multifunctional wound dressings with potent hemostatic, antibacterial, anti-inflammatory, and angiogenesis features for bolstering the healing of full-thickness wounds is sought after for clinical applications. We created bio-multifunctional composite sponges by coupling alginate and chitosan with Sargassum pallidum polysaccharides through electrostatic interactions, calcium ion (Ca²⁺) crosslinking, and lyophilization. Alginate/chitosan (AC) sponges with different concentrations of Sargassum pallidum polysaccharides were obtained and termed AC, ACS-1%, ACS-2.5%, and ACS-5%. ACS-1% and ACS-2.5% sponges exhibited uniform porosity, high water vapor transmission rate, high water absorption, as well as good hemostatic and antibacterial abilities. ACS-2.5% sponges facilitated wound closure and promoted angiogenesis and re-epithelialization in the dermis. These data suggest that ACS sponges containing a certain amount of Sargassum pallidum polysaccharides could be employed for treatment of full-thickness skin wounds.

Keywords: Sargassum pallidum polysaccharides; alginate; bio-multifunctional; chitosan; composite sponges; wound healing.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alginates / pharmacology
Anti-Bacterial Agents / pharmacology
Chitosan* / pharmacology
Hemostatics*
Polysaccharides / pharmacology
Sargassum*

Substances

Chitosan
Alginates
Polysaccharides
Anti-Bacterial Agents
Hemostatics

Grants and funding

This work was supported financially by Project of the Ph.D. Start-up Fund of Guangdong Medical University (GDMUB2021005, GDMUB2022032), the public service plat form of south China Sea for R&D marine biomedicine resources (2017C8A), Special Science and Technology Innovation Project of Guangdong Province, China (2019A01005, 2019A03023).