Importance of TGFβ in Cancer and Nematode Infection and Their Interaction-Opinion

Biomolecules. 2022 Oct 26;12(11):1572. doi: 10.3390/biom12111572.

Abstract

Historically, there has been little interaction between parasitologists and oncologists, although some helminth infections predispose to the development of tumours. In addition, both parasites and tumours need to survive immune attack. Recent research suggests that both tumours and parasites suppress the immune response to increase their chances of survival. They both co-opt the transforming growth factor beta (TGFβ) signalling pathway to modulate the immune response to their benefit. In particular, there is concern that suppression of the immune response by nematodes and their products could enhance susceptibility to tumours in both natural and artificial infections.

Keywords: TGFβ; TGFβ mimic; cancer; immunomodulation; nematode.

Publication types

  • Review

MeSH terms

  • Humans
  • Nematode Infections*
  • Neoplasms*
  • Transforming Growth Factor beta / metabolism

Substances

  • Transforming Growth Factor beta

Grants and funding

This research received no external funding.