Micro RNAs-The Small Big Players in Hepatitis E Virus Infection: A Comprehensive Review

Elitsa Golkocheva-Markova

doi:10.3390/biom12111543

Micro RNAs-The Small Big Players in Hepatitis E Virus Infection: A Comprehensive Review

Biomolecules. 2022 Oct 22;12(11):1543. doi: 10.3390/biom12111543.

Author

Elitsa Golkocheva-Markova¹

Affiliation

¹ NRL Hepatitis Viruses, Virology Department, National Center of Infectious and Parasitic Diseases, 1233 Sofia, Bulgaria.

Abstract

The molecular mechanism of hepatitis E virus (HEV) pathology is still unclear. The micro RNAs (miRNAs), of host or viral origin, interfere with virus replication and host environment in order to create an appropriate condition for the production of mature HEV progeny. Understanding the biogenesis and the interference of miRNAs with HEV will help to revile the mechanism of viral pathogenesis.

Keywords: HEV; HEV-miRNA; miRNA-122; miRNA-214.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Hepatitis E virus* / genetics
Hepatitis E* / genetics
Hepatitis E* / pathology
Humans
MicroRNAs* / genetics
Virus Replication / genetics

Substances

MicroRNAs

Grants and funding

This research was funded by the Bulgarian National Science Fund, grant number KP-06-N-33/2.