Improvement of the autoimmune phenomenon after treatment of primary hyperparathyroidism: Possible role of dynamics of parathyroid hormone-1-receptor in B-lymphocytes

Iván Posso-Osorio; Lady J Rios-Serna; Angie M Rosero; Diana Cárdenas; Gabriel J Tobón; Carlos A Cañas

doi:10.1016/j.jtauto.2022.100170

Improvement of the autoimmune phenomenon after treatment of primary hyperparathyroidism: Possible role of dynamics of parathyroid hormone-1-receptor in B-lymphocytes

J Transl Autoimmun. 2022 Oct 29:5:100170. doi: 10.1016/j.jtauto.2022.100170. eCollection 2022.

Authors

Iván Posso-Osorio^{1

2}, Lady J Rios-Serna¹, Angie M Rosero^{1

3}, Diana Cárdenas¹, Gabriel J Tobón⁴, Carlos A Cañas^{1

2}

Affiliations

¹ Universidad Icesi, CIRAT: Centro de Investigación en Reumatología, Autoinmunidad y Medicina Traslacional, Cali 760031, Colombia.
² Fundación Valle del Lili, Unidad de Reumatología, Cali, Colombia.
³ Universidad del Valle, Escuela de Bacteriología y Laboratorio Clínico, Facultad de Salud, Cali, Colombia.
⁴ Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, USA.

Abstract

We report a case of 65-year-old male patient with primary hyperparathyroidism (PHPT) who was admitted to the hospital for autoimmune manifestations (including autoimmune hepatitis and autoantibody development) and exhibited subsequent clinical and paraclinical improvement after parathyroidectomy. By flow cytometry, the expression of PTH receptor 1 (PTHR1) on B lymphocytes of peripheral blood was documented to be higher than that in healthy controls. After parathyroidectomy, autoimmune manifestations improved, while PTH1R expression on B-lymphocytes increased. The possible role of the dynamics of B-lymphocyte PTHR1 in the development of this autoimmune phenomenon is discussed.

Keywords: Autoimmune hepatitis; B cell; B lymphocytes; Parathyroid hormone; Parathyroidectomy.

Publication types

Case Reports