Olecranon bursitis caused by Scedosporium apiospermum in a patient treated with CAR-T cells

Willem J J Falkenburg; Marit Jalink; Marie José Kersten; Jochem B Buil; Karin van Dijk

doi:10.1016/j.mmcr.2022.10.002

Olecranon bursitis caused by Scedosporium apiospermum in a patient treated with CAR-T cells

Med Mycol Case Rep. 2022 Oct 28:38:33-35. doi: 10.1016/j.mmcr.2022.10.002. eCollection 2022 Dec.

Authors

Willem J J Falkenburg¹, Marit Jalink², Marie José Kersten², Jochem B Buil³, Karin van Dijk¹

Affiliations

¹ Department of Medical Microbiology and Infection Control, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
² Department of Haematology, Amsterdam University Medical Centers, Location University of Amsterdam, Amsterdam, the Netherlands.
³ Department of Medical Microbiology, Radboud University Medical Center, and Radboudumc - CWZ Center of Expertise for Mycology, Nijmegen, the Netherlands.

Abstract

Chimeric antigen receptor (CAR-) T cell therapy is a relatively new form of immunotherapy for hematological malignancies. Although patients are at increased risk of infection following CAR-T cell therapy, reports of fungal infections are scarce. We report a case of Scedosporium apiospermum infection causing bursitis of the elbow in a lymphoma patient after treatment with CAR-T cells. The fungal bursitis relapsed under posaconazole treatment, but was cured after surgical extirpation of the bursa.

Keywords: Bursitis; CAR-T cell therapy; Posaconazole; Scedosporium apiospermum; Voriconazole.

Publication types

Case Reports