Comparative evaluation of radionuclide therapy using 90Y and 177Lu

Abstract

Objective: Both ⁹⁰Y and ¹⁷⁷Lu are attractive β-emitters for radionuclide therapy and have been used in clinical practice. Nevertheless, comparative evaluation between ⁹⁰Y- and ¹⁷⁷Lu-labeled molecules has not been fully conducted. Thus, in this study, the features of ⁹⁰Y and ¹⁷⁷Lu for radionuclide therapy were assessed in tumor-bearing mice.

Methods: Two tumor cell lines with different growth rates were used. Biodistribution studies of ¹⁷⁷Lu-labeled antibodies (¹⁷⁷Lu-Abs) were conducted in each tumor-bearing mouse model. Subsequently, the therapeutic effect of ⁹⁰Y- and ¹⁷⁷Lu-Ab were assessed in tumor-bearing mice. The absorbed radiation dose for the tumor was estimated using the Monte Carlo simulation.

Results: ¹⁷⁷Lu-Abs demonstrated high tumor accumulation in both tumor-xerograph. In the fast-growing tumor model, ⁹⁰Y-Ab showed a better therapeutic effect than ¹⁷⁷Lu-Ab, reflecting a higher absorbed radiation dose of ⁹⁰Y-Ab than that of ¹⁷⁷Lu-Ab. In the slow-growing tumor model, both ⁹⁰Y- and ¹⁷⁷Lu-Ab showed an excellent therapeutic effect; however, ¹⁷⁷Lu-Ab had a longer efficacy period than ⁹⁰Y-Ab, which could be attributed to the longer half-life and better dose uniformity of ¹⁷⁷Lu than those of ⁹⁰Y.

Conclusions: To accomplish a maximum therapeutic effect, selecting ⁹⁰Y or ¹⁷⁷Lu, to depend on the growth rate of individual cancer, would be helpful.

Keywords: 177Lu; 90Y; Radionuclide therapy; Tumor growth rate.