Coexistence of Post-essential Thrombocythemia Myelofibrosis With Monoclonal Gammopathy of Undetermined Significance: A Case Report

Sarvani Reddy Allam; Mridula Sree Naagendran; Jaison Lawrence Alexander Santhi; Ratesh Khillan

doi:10.7759/cureus.29948

Coexistence of Post-essential Thrombocythemia Myelofibrosis With Monoclonal Gammopathy of Undetermined Significance: A Case Report

Cureus. 2022 Oct 5;14(10):e29948. doi: 10.7759/cureus.29948. eCollection 2022 Oct.

Authors

Sarvani Reddy Allam¹, Mridula Sree Naagendran², Jaison Lawrence Alexander Santhi³, Ratesh Khillan⁴

Affiliations

¹ Medicine, Katuri Medical College & Hospital, Guntur, IND.
² Medicine, PSG Institute of Medical Sciences & Research, Coimbatore, IND.
³ Medicine, Government Sivagangai Medical College & Hospital, Pudukkottai, IND.
⁴ Hematology/Oncology, Kingsbrook Jewish Medical Center, New York City, USA.

Abstract

Synchronous dual haematological neoplasms are always challenging in both diagnosis and treatment. Here, we report the case of a 73-year-old African American female patient with the coexistence of post-essential thrombocythemia myelofibrosis with MPL positive mutation and monoclonal gammopathy of undetermined significance (MGUS). Our management plan focuses on her anaemia and regular monitoring for observing MGUS transforming into an aggressive multiple myeloma.

Keywords: bone marrow; hematology-oncology; mgus; myelofibrosis; thrombocythemia.

Publication types

Case Reports