Chromosome organization is highly dynamic and plays an essential role during cell function. It was recently found that pairs of the homologous chromosomes are continuously separated at mitosis and display a haploid (1n) chromosome set, or "antipairing," organization in human cells. Here, we provide an introduction to the current knowledge of homologous antipairing in humans and its implications in human disease.
Keywords: Antipairing; Homologous chromosomes; Mitosis; Nuclear organization.
© 2022. The Author(s), under exclusive license to Springer Nature Switzerland AG.