With the rapid development of edge intelligence (EI) and machine learning (ML), the applications of Cyber-Physical Systems (CPS) have been discovered in all aspects of the life world. As one of its most essential branches, Medical CPS (MCPS) determines human health and medical treatment in the Internet of Everything (IOE) era. Knowledge sharing is the critical point of MCPS and has also been humanity's best dream through the ages. This paper explores a novel knowledge-sharing model in MCPS and takes a pulmonary nodule detection task as a significant case for building an Unet-based mask generator. A Classification-guided Module (CGM)-based discriminator with knowledge from EMRs is set against a generator to offer a promising result for each mask from the inexperienced participant of federated ML. After an iterative communication between the federated server and its clients for knowledge sharing, the segmented sub-image owns a coincident attribute distribution with that of the EMRs from the experts. Besides, the adversarial network augment the data to normalize the data distribution for all the clients as a remission for none independent identically distributed (non-IID) data problem. We implement a detection framework on the simulated EI environment following an existing adaptive synchronization strategy based on data sharing and median loss function. On 1304 scans of the merged dataset, our proposed framework can help boost the detection performance for most of the existing methods of pulmonary nodule detection.