Self-Assembling Peptide-Based Functional Biomaterials

Chembiochem. 2023 Jan 17;24(2):e202200582. doi: 10.1002/cbic.202200582. Epub 2022 Nov 30.

Abstract

Peptides can self-assemble into various hierarchical nanostructures through noncovalent interactions and form functional materials exhibiting excellent chemical and physical properties, which have broad applications in bio-/nanotechnology. The self-assembly mechanism, self-assembly morphology of peptide supramolecular architecture and their various applications, have been widely explored which have the merit of biocompatibility, easy preparation, and controllable functionality. Herein, we introduce the latest research progress of self-assembling peptide-based nanomaterials and review their applications in biomedicine and optoelectronics, including tissue engineering, anticancer therapy, biomimetic catalysis, energy harvesting. We believe that this review will inspire the rational design and development of novel peptide-based functional bio-inspired materials in the future.

Keywords: biomaterials; nanostructures; peptides; self-assembly; supramolecular chemistry.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocompatible Materials / chemistry
  • Biomimetic Materials*
  • Nanostructures* / chemistry
  • Nanotechnology
  • Peptides / chemistry

Substances

  • Biocompatible Materials
  • Peptides