Impacts of noncovalent interactions involving sulfur atoms on protein stability, structure, folding, and bioactivity

Volga Kojasoy; Dean J Tantillo

doi:10.1039/d2ob01602h

Impacts of noncovalent interactions involving sulfur atoms on protein stability, structure, folding, and bioactivity

Org Biomol Chem. 2022 Dec 21;21(1):11-23. doi: 10.1039/d2ob01602h.

Authors

Volga Kojasoy¹, Dean J Tantillo¹

Affiliation

¹ Department of Chemistry, University of California, Davis, 1 Shields Avenue, Davis, CA, 95616, USA. djtantillo@ucdavis.edu.

PMID: 36345987
DOI: 10.1039/d2ob01602h

Abstract

This review discusses the various types of noncovalent interactions in which sulfur atoms participate and their effects on protein stability, structure, folding and bioactivity. Current approaches and recommendations for modelling these noncovalent interactions (in terms of both geometries and interaction energies) are highlighted.

Publication types

Review
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Hydrogen Bonding
Protein Stability
Sulfur* / chemistry

Substances

Sulfur

Grants and funding

National Science Foundation