The epidemiology of COVID-19 has dramatically changed since the beginning of the pandemic as we witnessed significant changes in transmissibility and pathogenicity with the emergence of SARS-CoV-2 variants of concern (VoCs). Here I present and comment on working hypotheses about the evolutionary dynamics of the emergence of VoCs.
Keywords: COVID-19; SARS-CoV-2; immune escape; pathogenicity; transmission; variants of concern.
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