Cigarette smoke interacts with amiodarone toxicity in Saccharomyces cerevisiae

Houssein Al-Attrache; Iman Halloum; Lara Hammoud; Katia El Ghoz; Ziad Abdel-Razzak

doi:10.1002/jat.4413

Cigarette smoke interacts with amiodarone toxicity in Saccharomyces cerevisiae

J Appl Toxicol. 2023 May;43(5):764-768. doi: 10.1002/jat.4413. Epub 2022 Nov 26.

Authors

Houssein Al-Attrache^{1

2

3}, Iman Halloum¹, Lara Hammoud², Katia El Ghoz¹, Ziad Abdel-Razzak¹

Affiliations

¹ EDST and FS1, Lebanese University, Rafic Hariri Campus, Beirut, Lebanon.
² Faculty of Sciences-III, Lebanese University, Tripoli, Lebanon.
³ Faculty of Public Health, Section IV, Lebanese University, Zahleh, Lebanon.

PMID: 36343010
DOI: 10.1002/jat.4413

Abstract

Amiodarone (AMD) is an antiarrhythmic drug prescribed to treat ventricular tachycardia and fibrillation. However, it causes an unpredictable toxicity (idiosyncratic), which may depend on co-exposure to pollutants. AMD toxicity involves calcium homeostasis alteration and oxidative stress, which are also affected by cigarette smoke (CS). We investigated the interaction of CS-condensate (CSC), phenanthrene, and benzo(a)pyrene with AMD toxicity on Saccharomyces cerevisiae. AMD toxicity was reduced by CSC or phenanthrene. Benzo(a)pyrene mildly decreased AMD toxicity on the wild-type strain, but not on the catalase-CTT1 mutant. This latter and other mutants in glucose receptor-GPR1 or calcium transporter-PMR1 showed lower antagonistic effect to AMD by CSC or phenanthrene relative to the wild type, suggesting roles of oxidative stress, calcium homeostasis, and hexose-sensing in this interaction.

Keywords: Saccharomyces cerevisiae; amiodarone; calcium homeostasis; catalase; cigarette smoke; nutrient sensing.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amiodarone* / toxicity
Benzo(a)pyrene / toxicity
Calcium
Cigarette Smoking*
Nicotiana
Saccharomyces cerevisiae / genetics

Substances

Amiodarone
Benzo(a)pyrene
Calcium