Surface modification of two-dimensional layered double hydroxide nanoparticles with biopolymers for biomedical applications

Marko Pavlovic; Adél Szerlauth; Szabolcs Muráth; Gábor Varga; Istvan Szilagyi

doi:10.1016/j.addr.2022.114590

Surface modification of two-dimensional layered double hydroxide nanoparticles with biopolymers for biomedical applications

Adv Drug Deliv Rev. 2022 Dec:191:114590. doi: 10.1016/j.addr.2022.114590. Epub 2022 Oct 29.

Authors

Marko Pavlovic¹, Adél Szerlauth², Szabolcs Muráth³, Gábor Varga⁴, Istvan Szilagyi⁵

Affiliations

¹ Department of Physics and John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; BioSense Institute, University of Novi Sad, Dr Zorana Djindjica 1, Novi Sad 21000, Serbia. Electronic address: markopavlovic@seas.harvard.edu.
² MTA-SZTE Lendület Biocolloids Research Group, University of Szeged, Rerrich Béla tér 1, Szeged 6720, Hungary; Department of Physical Chemistry and Materials Science, University of Szeged, Rerrich Béla tér 1, Szeged 6720, Hungary.
³ Department of Solid State Chemistry, University of Chemistry and Technology, Technická 1905/5, Prague 16628, Czech Republic.
⁴ Department of Physical Chemistry and Materials Science, University of Szeged, Rerrich Béla tér 1, Szeged 6720, Hungary.
⁵ MTA-SZTE Lendület Biocolloids Research Group, University of Szeged, Rerrich Béla tér 1, Szeged 6720, Hungary; Department of Physical Chemistry and Materials Science, University of Szeged, Rerrich Béla tér 1, Szeged 6720, Hungary. Electronic address: szistvan@chem.u-szeged.hu.

PMID: 36341860
DOI: 10.1016/j.addr.2022.114590

Abstract

Layered double hydroxides (LDHs) are appealing nanomaterials for (bio)medical applications and their potential is threefold. One can gain advantage of the structure of LDH frame (i.e., layered morphology), anion exchanging property towards drugs with acidic character and tendency for facile surface modification with biopolymers. This review focuses on the third aspect, as it is necessary to evaluate the advantages of polymer adsorption on LDH surfaces. Beside the short discussion on fundamental and structural features of LDHs, LDH-biopolymer interactions will be classified in terms of the effect on the colloidal stability of the dispersions. Thereafter, an overview on the biocompatibility and biomedical applications of LDH-biopolymer composite materials will be given. Finally, the advances made in the field will be summarized and future research directions will be suggested.

Keywords: Biopolymer; Carrier material; Layered double hydroxide; Nanocomposite; Surface modification.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Adsorption
Biopolymers
Humans
Hydroxides* / chemistry
Nanoparticles* / chemistry

Substances

hydroxide ion
Hydroxides
Biopolymers