A binocular perception deficit characterizes prey pursuit in developing mice

Kelsey Allen; Rocio Gonzalez-Olvera; Milen Kumar; Ting Feng; Simon Pieraut; Jennifer L Hoy

doi:10.1016/j.isci.2022.105368

A binocular perception deficit characterizes prey pursuit in developing mice

iScience. 2022 Oct 17;25(11):105368. doi: 10.1016/j.isci.2022.105368. eCollection 2022 Nov 18.

Authors

Kelsey Allen¹, Rocio Gonzalez-Olvera¹, Milen Kumar¹, Ting Feng¹, Simon Pieraut¹, Jennifer L Hoy¹

Affiliation

¹ Department of Biology, University of Nevada, Reno, Reno, NV 89557, USA.

Abstract

Integration of binocular information at the cellular level has long been studied in the mouse model to uncover the fundamental developmental mechanisms underlying mammalian vision. However, we lack an understanding of the corresponding ontogeny of visual behavior in mice that relies on binocular integration. To address this major outstanding question, we quantified the natural visually guided behavior of postnatal day 21 (P21) and adult mice using a live prey capture assay and a computerized-spontaneous perception of objects task (C-SPOT). We found a robust and specific binocular visual field processing deficit in P21 mice as compared to adults that corresponded to a selective increase in c-Fos expression in the anterior superior colliculus (SC) of the juveniles after C-SPOT. These data link a specific binocular perception deficit in developing mice to activity changes in the SC.

Keywords: Biological sciences; Neuroscience; Sensory neuroscience.

Abstract

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